黑曲霉转化中药化学成分研究进展

吴德超, 赵正权, 李运芝, 何方丽, 曲扬

中国药学杂志 ›› 2022, Vol. 57 ›› Issue (14) : 1153-1160.

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中国药学杂志
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中国药学杂志 ›› 2022, Vol. 57 ›› Issue (14) : 1153-1160. DOI: 10.11669/cpj.2022.14.003
综述

黑曲霉转化中药化学成分研究进展

  • 吴德超, 赵正权, 李运芝, 何方丽, 曲扬*
作者信息 +

Research Progress on the Chemical Constituents of Traditional Chinese Medicine Transformed by Aspergillus niger

  • WU De-chao, ZHAO Zheng-quan, LI Yun-zhi, HE Fang-li, QU Yang*
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文章历史 +

摘要

目的 中药作为中华民族的瑰宝,其有效成分种类繁多、临床应用广泛,对中药材的开发及利用一直是研究热题,其中微生物转化更是中药现代化开发的热点。黑曲霉作为一类广泛使用、安全可靠的菌株,能够分泌酯酶、糖苷酶、羟化酶等酶,能够使中药中的化学成分发生的羟基化、脱羟基、甲基化、脱甲基、羰基还原、去糖基化等反应,从而形成具有新颖结构的活性化合物或药物中间体,为中药化学成分的研究提供了新的开发思路。该文综述了以黑曲霉作为发酵菌株生产的酶对中药化学成分转化以及作用位点的研究进展,以期进一步揭开黑曲霉菌株发酵中药成分原理。

Abstract

As a treasure of the Chinese nation, traditional Chinese medicine has a wide variety of active ingredients and extensive clinical applications. The development and utilization of Chinese medicinal materials has been a hot research topic, and microbial transformation is a hot topic in the modern development of Chinese medicine. As a widely used, safe and reliable strain, Aspergillus niger secrets various enzymes including esterase, glycosidase, hydroxylase, etc, which can cause hydroxylation, dehydroxylation, methylation,demethylation, carbonylreduction, and deglycosylation of chemical components in traditional Chinese medicine, thereby forming active compounds or drug intermediates with novel structures, providing new development ideas for the research of chemical components of Chinese medicine. This manuscript summarizes the research progress on the transformation and the reactive positions of effective chemical components in Chinese medicine by enzymes produced by Aspergillus niger as a fermentation strain, in order to further reveal the principle of the fermentation of Chinese medicine by Aspergillus niger.

关键词

中药材 / 发酵 / 生物转化 / 黑曲霉 / 酶

Key words

Chinese medicinal material / fermentation / biotransformation / Aspergillus niger / enzyme

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导出引用
吴德超, 赵正权, 李运芝, 何方丽, 曲扬. 黑曲霉转化中药化学成分研究进展[J]. 中国药学杂志, 2022, 57(14): 1153-1160 https://doi.org/10.11669/cpj.2022.14.003
WU De-chao, ZHAO Zheng-quan, LI Yun-zhi, HE Fang-li, QU Yang. Research Progress on the Chemical Constituents of Traditional Chinese Medicine Transformed by Aspergillus niger[J]. Chinese Pharmaceutical Journal, 2022, 57(14): 1153-1160 https://doi.org/10.11669/cpj.2022.14.003
中图分类号： R282.4   

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基金

辽宁省教育厅科学研究项目资助(L201949);辽宁省大学生创新创业训练计划项目资助(201910162061)
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